. For the fourth successive race Valentino Rossi and Casey Stoner fill the top two slots on the grid.
. Valentino Rossi starts from pole for the first time since the Italian Grand Prix; it is his first pole at a race held in the USA. If Rossi wins the race he will take the record for most premier-class victories from Giacomo Agostini, a record that has stood since Agostini took his final victory at the West German Grand Prix in 1976 at the Nurburgring riding the MV Agusta factory machine.
. Rossi's victory at Mugello earlier in the year is his only victory from the last seven occasions he has started on pole. Having already won at Laguna Seca, Rossi has the opportunity to become the first rider ever to take two MotoGP victories in the USA in the same season.
. Ben Spies is higher up the grid than any wild-card or replacement rider since Troy Bayliss was 2nd fastest qualifier at the Valencia GP in 2006.
. If Loris Capirossi finishes in the top three it will be his 100th podium in Grand Prix racing and he would also become only the second rider in Grand Prix history to pass the milestone of 3000 points across all classes. The only other rider to achieve this is Rossi.
. Shinya Nakano and Valentino Rossi are the only two riders across all three GP classes to have scored points at every race in 2008.
. If Colin Edwards finishes third at Indianapolis he will equal the 124 points he has achieved in each of the past two seasons.
. Dunlop are scheduled to take their 200th consecutive victory in the 250cc class. The last non-Dunlop win in the class was Tetsuya Harada's victory at the Indonesian GP in 1996.
. Marco Simoncelli starts from pole for the fourth time in 2008. He has had three podium finishes, including one win, from his three previous poles this year.
. Hector Barbera is starting from the front row for the eighth successive race.
. Mika Kallio starts from his best grid position since he was 3rd on the grid in China - a race he went on to win.
. Alex Debon, who is making his 120th GP start, has qualified on the front row for the 7th time in 2008.
. Alvaro Bautista has finished on the podium at the last six successive races.
. Pol Espargaro starts from pole for the second time in his GP career. His other pole was at Catalunya earlier this year where he went on to finish 2nd, his best ever GP result.
. Mike di Meglio returns to the front row for the first time since the Dutch TT. Di Meglio's crash at Misano resulted in him failing to score points for the first time this year.
. For the second time this year, Derbi riders have taken the top two spots on the grid - the other occasion this happened was at Catalunya.
. For the first time in his GP career Stefan Bradl has qualified as the top Aprilia rider on the grid.
. Danny Webb is starting from the front row for the second time, equalling his best ever grid position achieved at the Portuguese GP earlier this year.
. Andrea Iannone has not returned to the podium in the eight races since he won the Chinese Grand Prix back in May.
. After being on the podium three times in the first five races of the year, Nicolas Terol has now gone seven races without a top three finish.
. Gabor Talmacsi, who will be aiming for back-to-back GP victories for the first time, has qualified down in 16th place - his lowest grid position since he was the 17th-placed qualifier in Qatar in 2004 riding a Malaguti.
. At the age of 15 years and 38 days PJ Jacobsen will become the youngest ever American rider to start a Grand Prix, taking the record from Jason di Salvo.